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In July 2021, the FDA issued Ardelyx a Complete Response Letter in which it stated that the molecule’s effect size was “small and of unclear clinical significance.” Then, in November 2022, an FDA advisory committee voted 9-4 that Xphozah’s benefits outweighed its risks
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NICE guidance (TA875) recommends that Wegovy treatment in England is initiated within specialist weight management services, with ongoing monitoring and support
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